[地尔硫䓬对稳定型运动诱发型心绞痛和血管痉挛型心绞痛患者的抗心绞痛作用与硝苯地平作用的比较]
[The anti-anginal effect of diltiazem in patients with stable exercise-induced stenocardia and vasospastic stenocardia compared with the effect of nifedipine].
作者信息
Kocherga E Iu, Glukhovtsev E V, Gratsianskiĭ N A
出版信息
Kardiologiia. 1990 Feb;30(2):29-31.
Paired bicycle ergometric tests were performed in 13 patients with stable exercise-induced angina who took a single dose of diltiazem (120 mg) and nifedipine (30 mg). Four patients with vasospastic angina underwent repeat ergometrine tests along with the both drugs given in the same doses. The two drugs significantly increased exercise tolerance: exercise time was increased by 83% with diltiazem and by 41.9% with nifedipine, its capacity was elevated by 78.9 and 30.2%, respectively, the "double product" at the peak of exercise was raised by 17.0 and 18.7%, respectively). With intravenous injection of ergometrine, diltiazem and nifedipine eliminated or delayed the spastic reaction of coronary arteries in most cases.
对13例稳定型运动诱发心绞痛患者进行了配对自行车测力计测试，这些患者服用了单剂量的地尔硫卓（120毫克）和硝苯地平（30毫克）。4例变异性心绞痛患者接受了重复的麦角新碱测试，同时给予相同剂量的这两种药物。这两种药物显著提高了运动耐量：地尔硫卓使运动时间增加了83%，硝苯地平使运动时间增加了41.9%，运动能力分别提高了78.9%和30.2%，运动峰值时的“双乘积”分别提高了17.0%和18.7%。静脉注射麦角新碱时，地尔硫卓和硝苯地平在大多数情况下消除或延迟了冠状动脉的痉挛反应。
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