Service of ENT-Head and Neck Surgery, University Hospital Complex of Santiago de Compostela (CHUS), Spain.
Otolaryngol Head Neck Surg. 2012 Jan;146(1):81-7. doi: 10.1177/0194599811421110. Epub 2011 Sep 7.
No specific epidemiology data are available for carcinoma of the uvula. This study aims to analyze the epidemiological characteristics and treatment outcomes of carcinoma of the uvula at the authors' institution.
Case series with chart review.
Service of ENT-Head and Neck Surgery, University Hospital Complex of Santiago de Compostela (CHUS), Spain.
Retrospective epidemiological study of 21 male patients, mean age 57.52 years, diagnosed with squamous cell carcinoma of the uvula in the CHUS between January 1990 and June 2009.
Most patients presented with odynophagia and exophytic lesions microscopically consistent with moderately differentiated squamous cell carcinoma. Despite the size of the lesions (T1 and T2), more than half of the patients had lymph node metastases at diagnosis. More than 90.0% of patients with lesions larger than 1 cm presented with lymph node metastases. Although more than 70.0% of patients underwent a neck dissection in the first year after diagnosis, only 25.0% were free of metastatic disease. Recurrences occurred at a mean of 14 months from baseline in more than 50.0% of cases. Of the patients, 52.4% died, with a median survival of 38.15 months after diagnosis. The overall 5-year survival was 39.0%. According to tumor size, 5-year survival was 53.0% for T1 and 27.0% for T2.
According to the data, clinical features of carcinoma of the uvula correspond with aggressive tumors, with rapid onset and a major negative impact regardless of tumor size at diagnosis. Early stage patients benefit significantly from surgical treatments with neck dissections.
关于悬雍垂癌，尚无特定的流行病学数据。本研究旨在分析作者所在机构悬雍垂癌的流行病学特征和治疗结果。
病例系列，回顾性研究。
西班牙圣地亚哥德孔波斯特拉大学医院综合服务（CHUS）耳鼻喉头颈外科。
回顾性分析了 1990 年 1 月至 2009 年 6 月在 CHUS 诊断为鳞状细胞癌的 21 例男性患者的流行病学资料，平均年龄为 57.52 岁。
大多数患者表现为咽痛和外生性病变，显微镜下符合中分化鳞状细胞癌。尽管病变大小（T1 和 T2），但超过一半的患者在诊断时已有淋巴结转移。超过 90.0%的病变大于 1cm 的患者有淋巴结转移。尽管超过 70.0%的患者在诊断后第一年接受了颈部清扫术，但只有 25.0%的患者无转移性疾病。超过 50.0%的患者在基线后 14 个月内复发。52.4%的患者死亡，诊断后中位生存时间为 38.15 个月。总的 5 年生存率为 39.0%。根据肿瘤大小，T1 的 5 年生存率为 53.0%，T2 的 27.0%。
根据数据，悬雍垂癌的临床特征与侵袭性肿瘤相对应，无论诊断时肿瘤大小如何，发病迅速且对预后有重大负面影响。早期患者从颈部清扫术等外科治疗中获益显著。
