Saito E, Ichikawa Y, Homma M
J Clin Endocrinol Metab. 1979 May;48(5):861-3. doi: 10.1210/jcem-48-5-861.
A rapid ACTH test was used to investigate the direct effect of glucocorticoid on the steroidogenesis by the adrenal cortex in man. The plasma cortisol response to 250 microgram iv synthetic alpha-ACTH-(1--24) (Cortrosyn) was determined in normal subjects pretreated with 2 and 12 mg dexamethasone. The 15- and 30-min increments in plasma cortisol levels in response to ACTH injection after pretreatment with 12 mg dexamethasone were significantly suppressed compared to values obtained after pretreatment with 2 mg dexamethasone. The present study suggests that there is a direct inhibitory effect of glucocorticoid on adrenocortical steroidogenesis in man.
采用快速促肾上腺皮质激素（ACTH）试验研究糖皮质激素对人肾上腺皮质类固醇生成的直接作用。在预先给予2毫克和12毫克地塞米松的正常受试者中，测定静脉注射250微克合成α-促肾上腺皮质激素-（1-24）（考的索）后血浆皮质醇的反应。与预先给予2毫克地塞米松后获得的值相比，预先给予12毫克地塞米松后注射促肾上腺皮质激素（ACTH）后血浆皮质醇水平在15分钟和30分钟时的升高明显受到抑制。本研究表明，糖皮质激素对人肾上腺皮质类固醇生成有直接抑制作用。
