Edwards K M, Karzon D T
Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Pediatr Clin North Am. 1990 Jun;37(3):549-66. doi: 10.1016/s0031-3955(16)36904-8.
Concern over adverse reactions temporally associated with whole cell pertussis vaccine and advances in the understanding of the Bordetella pertussis organism have led to a new generation of more purified acellular vaccines. The biology of the pertussis organism, epidemiology of disease, vaccine development over the decades, and vaccine efficacy and adverse reaction data from whole cell and acellular vaccine trials are presented. Questions that remain to be answered before acellular vaccine replaces conventional vaccine are defined, and future studies addressing these questions are proposed.
对与全细胞百日咳疫苗存在时间关联的不良反应的担忧，以及对百日咳博德特氏菌生物体认识的进展，催生了新一代更纯化的无细胞疫苗。本文介绍了百日咳生物体的生物学特性、疾病流行病学、数十年来的疫苗研发情况，以及全细胞和无细胞疫苗试验的疫苗效力和不良反应数据。明确了在无细胞疫苗取代传统疫苗之前仍有待解答的问题，并提出了针对这些问题的未来研究方向。
