上下文对密码子使用偏好性低的基因中同义密码子使用的影响。
The effect of context on synonymous codon usage in genes with low codon usage bias.
作者信息
Bulmer M
机构信息
Department of Statistics, Oxford, UK.
出版信息
Nucleic Acids Res. 1990 May 25;18(10):2869-73. doi: 10.1093/nar/18.10.2869.
Abstract
The effect of neighbouring bases on the usage of synonymous codons in genes with low codon usage bias in yeast and E. coli is examined. The codon adaptation index is employed to identify a group of genes in each organism with low codon usage bias, which are likely to be weakly expressed. A similar pattern is found in complementary sequences with respect to synonymous usage of A vs G or of U vs C. It is suggested that this may reflect an effect of context on mutation rates in weakly expressed genes.
摘要
研究了相邻碱基对酵母和大肠杆菌中密码子使用偏好较低的基因中同义密码子使用情况的影响。密码子适应指数用于在每个生物体中识别一组密码子使用偏好较低的基因，这些基因可能是低表达的。在关于A与G或U与C的同义使用的互补序列中发现了类似的模式。有人认为，这可能反映了上下文对低表达基因中突变率的影响。
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Choice of base at silent codon site 3 is not selectively neutral in eucaryotic structural genes: it maintains excess short runs of weak and strong hydrogen bonding bases.在真核生物结构基因中，沉默密码子位点3处碱基的选择并非是选择性中性的：它维持了过多的由弱氢键碱基和强氢键碱基组成的短串联。
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Contextual constraints on synonymous codon choice.同义密码子选择的上下文限制
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4
Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes.原核基因中的密码子偏好使用：最佳密码子 - 反密码子相互作用能量与高效表达基因中的选择性密码子使用
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Codon context effects in missense suppression.错义抑制中的密码子上下文效应。
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6
Evidence for use of rare codons in the dnaG gene and other regulatory genes of Escherichia coli.大肠杆菌dnaG基因及其他调控基因中稀有密码子使用的证据。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):687-91. doi: 10.1073/pnas.80.3.687.
7
Context effects: translation of UAG codon by suppressor tRNA is affected by the sequence following UAG in the message.上下文效应：抑制性tRNA对UAG密码子的翻译受到信使RNA中UAG之后序列的影响。
J Mol Biol. 1983 Feb 15;164(1):73-87. doi: 10.1016/0022-2836(83)90088-8.
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Sense codons are found in specific contexts.有义密码子存在于特定的上下文环境中。
J Mol Biol. 1985 Apr 20;182(4):529-40. doi: 10.1016/0022-2836(85)90239-6.
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Mono- through hexanucleotide composition of the Escherichia coli genome: a Markov chain analysis.大肠杆菌基因组的单核苷酸至六核苷酸组成：马尔可夫链分析
Nucleic Acids Res. 1987 Mar 25;15(6):2611-26. doi: 10.1093/nar/15.6.2611.
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