Oxford University Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford.
Clin Med (Lond). 2011 Jun;11(3):292-3. doi: 10.7861/clinmedicine.11-3-292.
The depolarising neuromuscular blocking agent suxamethonium chloride, frequently used during endotracheal intubation, is contraindicated in patients with chronic denervation in whom it can cause a life-threatening hyperkalaemic reaction, thought to be mediated through upregulation of nicotinic alpha7 acetylcholine receptors. An underlying neuromuscular disorder should be considered in all patients with acute respiratory insufficiency, and an alternative neuromuscular blocking drug must be used if there is any possibility of widespread denervation.
去极化神经肌肉阻滞剂琥珀胆碱氯化物，常用于气管插管，在慢性去神经支配的患者中禁用，因为它可能引起危及生命的高钾反应，被认为是通过上调烟碱型乙酰胆碱受体 α7 亚单位介导的。所有急性呼吸功能不全的患者都应考虑存在潜在的神经肌肉疾病，如果存在广泛去神经支配的任何可能性，则必须使用替代的神经肌肉阻滞剂。
