Physicochimie Curie, Institut Curie/CNRS-UMR/UPMC, Paris, France.
Phys Rev Lett. 2011 Aug 12;107(7):078104. doi: 10.1103/PhysRevLett.107.078104. Epub 2011 Aug 11.
We study theoretically the shapes of a dividing epithelial monolayer of cells lying on top of an elastic stroma. The negative tension created by cell division provokes a buckling instability at a finite wave vector leading to the formation of periodic arrays of villi and crypts. The instability is similar to the buckling of a metallic plate under compression. We use the results to rationalize the various structures of the intestinal lining observed in vivo. Taking into account the coupling between cell division and local curvature, we obtain different patterns of villi and crypts, which could explain the different morphologies of the small intestine and the colon.
我们从理论上研究了位于弹性基质上的分裂上皮细胞单层的形状。细胞分裂产生的负张力在有限的波矢量下引发了屈曲不稳定性，导致绒毛和隐窝的周期性阵列形成。这种不稳定性类似于受压金属板的屈曲。我们使用这些结果来合理化体内观察到的各种肠道内层结构。考虑到细胞分裂和局部曲率之间的耦合，我们得到了不同的绒毛和隐窝模式，这可以解释小肠和结肠的不同形态。
