通过对三株1型艾滋病毒分离株进行全基因组分析在新加坡鉴定出新的CRF51_01B
Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.
作者信息
Ng Oon Tek, Eyzaguirre Lindsay M, Carr Jean K, Chew Kuan Kiat, Lin Li, Chua Arlene, Leo Yee Sin, Redd Andrew D, Quinn Thomas C, Laeyendecker Oliver
机构信息
Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA.
出版信息
AIDS Res Hum Retroviruses. 2012 May;28(5):527-30. doi: 10.1089/aid.2011.0177. Epub 2011 Sep 23.
Abstract
A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.
摘要
新加坡最近一项HIV-1分子流行病学调查发现了一种新型CRF01_AE/B重组形式，在109份患者样本中有13份（11.9%）属于这种类型。从这13名患者中的3名患者的外周血单核细胞DNA中获取了近全长序列，以对新型CRF01_AE/B重组形式进行特征分析。这三株分离株具有由CRF01_AE和B亚型组成的重组结构，并且具有相同的断点。由于这三名患者在流行病学上并无关联，因此这种重组形式被命名为CRF51_01B。新型重组形式的发现表明新加坡存在持续活跃的HIV-1传播。
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