Ou Weidong, Li Kang, Feng Yi, Huang Qiao, Ge Zhangwen, Sun Jia, Zhou Zhehua, Liang Yanling, Xing Hui, Liang Hao, Shao Yiming
1 Guangxi Key Laboratory of AIDS Prevention and Treatment and Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, School of Public Health, Guangxi Medical University , Nanning, China .
2 Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China .
AIDS Res Hum Retroviruses. 2019 Apr;35(4):414-418. doi: 10.1089/AID.2018.0197. Epub 2018 Nov 1.
To date, there are 16 types of CRF01_AE/B circulating recombinant forms identified, and most of them are distributed in Asian countries such as China, Malaysia, and Singapore. Previous HIV molecular epidemiological surveys showed that CRF01_AE (27.6%) and B (9.6%) subtypes are predominant strains in mainland of China. At the same time, the HIV-1 virus spreads faster in the men who have sex with men (MSM) population than in other risk groups. In Shanghai district, ∼66.0% of newly reported cases were infected through homosexual transmission. In this study, we report a novel recombinant strain of CRF01_AE/B. The near full-length genome phylogenetic tree showed that the strain clustered with the CRF01_AE reference sequence and placed in the peripheral position within the branch of the CRF01_AE strain. Subregional evolutionary results indicated that the CRF01_AE subtype was derived from cluster 4 of CRF01_AE, which is mainly distributed in northern China. The subtype B was correlated with the U.S./Europe B, which are widely prevalent in the Chinese MSM population. In recent years, a large number of recombinant forms between CRF01_AE and B strains are continuously emerging in China. Therefore, understanding the current epidemic recombinant forms will have significant implications for prevention and treatment of HIV/AIDS.
迄今为止，已鉴定出16种CRF01_AE/B循环重组形式，其中大多数分布在中国、马来西亚和新加坡等亚洲国家。先前的HIV分子流行病学调查显示，CRF01_AE（27.6%）和B（9.6%）亚型是中国内地的主要毒株。同时，HIV-1病毒在男男性行为者（MSM）人群中的传播速度比其他风险群体更快。在上海地区，约66.0%的新报告病例是通过同性传播感染的。在本研究中，我们报告了一种新型的CRF01_AE/B重组毒株。近乎全长基因组系统发育树显示，该毒株与CRF01_AE参考序列聚类，并位于CRF01_AE毒株分支的外围位置。亚区域进化结果表明，CRF01_AE亚型源自CRF01_AE的第4簇，主要分布在中国北方。B亚型与美国/欧洲B型相关，在中国MSM人群中广泛流行。近年来，中国不断出现大量CRF01_AE和B毒株之间的重组形式。因此，了解当前的流行重组形式对HIV/AIDS的预防和治疗具有重要意义。
