Section of Pediatric Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, University of Chicago, Illinois, USA.
Antioxid Redox Signal. 2012 Jan 15;16(2):171-7. doi: 10.1089/ars.2011.4189. Epub 2011 Oct 12.
Pediatric obstructive sleep apnea (OSA) may lead to neurocognitive dysfunction, but not in everyone affected. The frequencies of NADPH oxidase (NOX) polymorphisms in the p22phox subunit were similar between children with OSA and controls, except for rs6520785 and rs4673, the latter being significantly more frequent among the OSA children without deficits than with deficits (p<0.02). Similarly, 8-hydroxydeoxyguanine urine levels and NOX activity were lower among children without cognitive deficits and particularly among those with the rs4673 polymorphism. Thus, polymorphisms within the NOX gene or its functional subunits may account for important components of the variance in cognitive function deficits associated with OSA in children.
儿童阻塞性睡眠呼吸暂停（OSA）可能导致神经认知功能障碍，但并非所有受影响的儿童都会如此。在 p22phox 亚单位中，NADPH 氧化酶（NOX）多态性的频率在 OSA 儿童和对照组之间相似，除了 rs6520785 和 rs4673，后者在没有认知缺陷的 OSA 儿童中比有缺陷的儿童更为常见（p<0.02）。同样，无认知缺陷儿童的尿液 8-羟基脱氧鸟苷水平和 NOX 活性较低，特别是具有 rs4673 多态性的儿童。因此，NOX 基因或其功能亚单位内的多态性可能是与儿童 OSA 相关的认知功能缺陷差异的重要组成部分。
