巴基斯坦丙型肝炎病毒基因型：系统综述。
Hepatitis C virus genotypes in Pakistan: a systemic review.
机构信息
Department of Zoology, Islamia College (Public Sector University) Peshawar, Khyber Pakhtunkhwa, Pakistan.
出版信息
Virol J. 2011 Sep 8;8:433. doi: 10.1186/1743-422X-8-433.
BACKGROUND AND AIM
Phylogenetic analysis has led to the classification of hepatitis C virus (HCV) into 1-6 major genotypes. HCV genotypes have different biological properties, clinical outcome and response to antiviral treatment and provide important clues for studying the epidemiology, transmission and pathogenesis. This article deepens the current molecular information about the geographical distribution of HCV genotypes and subgenotypes in population of four provinces of Pakistan. 34 published papers (1996-2011) related to prevalence of HCV genotypes/serotypes and subgenotypes in Pakistan were searched.
RESULT
HCV genotype/s distribution from all 34 studies was observed in 28,400 HCV infected individuals in the following pattern: 1,999 (7.03%) cases of genotype 1; 1,085 (3.81%) cases of genotype 2; 22,429 (78.96%) cases of genotype 3; 453 (1.59%) cases of genotype 4; 29 (0.10%) cases of genotype 5; 37 (0.13%) cases of genotype 6; 1,429 (5.03%) cases of mixed genotypes, and 939 (3.30%) cases of untypeable genotypes. Overall, genotype 3a was the predominant genotype with a rate of 55.10%, followed by genotype 1a, 3b and mixed genotype with a rate of 10.25%, 8.20%, and 5.08%, respectively; and genotypes 4, 5 and 6 were rare. Genotype 3 occurred predominately in all the provinces of Pakistan. Second more frequently genotype was genotype 1 in Punjab province and untypeable genotypes in Sindh, Khyber Pakhtunkhwa and Balochistan provinces.
背景与目的
系统发生分析将丙型肝炎病毒（HCV）分为 1-6 种主要基因型。HCV 基因型具有不同的生物学特性、临床结局和抗病毒治疗反应，为研究其流行病学、传播和发病机制提供了重要线索。本文深入探讨了目前关于巴基斯坦四个省份 HCV 基因型和亚型在人群中的地理分布的分子信息。检索了 34 篇（1996-2011 年）与巴基斯坦 HCV 基因型/血清型流行情况相关的已发表文献。
结果
在对所有 34 项研究中，在 28400 例 HCV 感染个体中观察到 HCV 基因型/亚型分布情况如下：1 型 999 例（7.03%）；2 型 1085 例（3.81%）；3 型 22429 例（78.96%）；4 型 453 例（1.59%）；5 型 29 例（0.10%）；6 型 37 例（0.13%）；混合基因型 1429 例（5.03%）；未定型基因型 939 例（3.30%）。总体而言，基因型 3a 是最主要的基因型，占 55.10%，其次是基因型 1a、3b 和混合基因型，分别占 10.25%、8.20%和 5.08%；基因型 4、5 和 6 则较为少见。基因型 3 在巴基斯坦所有省份均占主导地位。其次，旁遮普省以基因型 1 为主，信德省、开伯尔-普赫图赫瓦省和俾路支省以未定型基因型为主。
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