在开伯尔-普赫图赫瓦省卫生保健工作者中的丙型肝炎病毒分子流行病学。
Molecular epidemiology of hcv among health care workers of khyber pakhtunkhwa.
机构信息
Molecular Parasitology and Virology Laboratory, Department of Zoology, Kohat University Kohat Khyber Pakhtunkhwa, Pakistan.
出版信息
Virol J. 2011 Mar 8;8:105. doi: 10.1186/1743-422X-8-105.
BACKGROUND
Studies of the molecular epidemiology and risk factors for hepatitis C virus (HCV) in health care workers (HCWs) of Peshawar, Khyber Pakhtunkhwa region are scarce. Lack of awareness about the transmission of HCV and regular blood screening is contributing a great deal towards the spread of hepatitis C. This study is an attempt to investigate the prevalence of HCV and its possible association with both occupational and non-occupational risk factors among the HCWs of Peshawar.
RESULTS
Blood samples of 824 HCWs, aged between 20-59 years were analysed for anti-HCV antibodies, HCV RNA and HCV genotypes by Immunochromatographic tests and PCR. All relevant information was obtained from the HCWs with the help of a questionnaire. The study revealed that 4.13% of the HCWs were positive for HCV antibodies, while HCV RNA was detected in 2.79% of the individuals. The most predominant HCV genotype was 3a and 2a.
CONCLUSION
A program for education about occupational risk factors and regular blood screening must be implemented in all healthcare setups of Khyber Pakhtunkhwa province in order to help reduce the burden of HCV infection.
背景
在白沙瓦、开伯尔-普赫图赫瓦省的卫生保健工作者（HCWs）中，有关丙型肝炎病毒（HCV）的分子流行病学和危险因素的研究很少。缺乏对 HCV 传播的认识以及定期的血液筛查极大地促进了丙型肝炎的传播。本研究试图调查白沙瓦 HCWs 中 HCV 的流行情况及其与职业和非职业危险因素的可能关联。
结果
对年龄在 20-59 岁之间的 824 名 HCWs 的血液样本进行了抗 HCV 抗体、HCV RNA 和 HCV 基因型的免疫色谱检测和 PCR 分析。通过问卷从 HCWs 那里获得了所有相关信息。研究表明，4.13%的 HCWs 抗 HCV 抗体阳性，2.79%的个体检测到 HCV RNA。最主要的 HCV 基因型是 3a 和 2a。
结论
必须在开伯尔-普赫图赫瓦省的所有医疗保健机构实施有关职业危险因素和定期血液筛查的教育计划，以帮助减轻 HCV 感染的负担。
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