Umar Muhammad, Bushra Hamama Tul, Ahmad Masood, Data Available, Ahmad Masood, Khurram Muhammad, Usman Saima, Arif Mohammad, Adam Tashfeen, Minhas Zahid, Arif Adnan, Naeem Abdul, Ejaz Khushnud, Butt Zameer, Bilal Muhammad
Department of Medicine, Rawalpindi Medical College, Holy Family Hospital, Rawalpindi, Pakistan.
Hepat Mon. 2010 Summer;10(3):205-14. Epub 2010 Sep 1.
Hepatitis C virus (HCV) infection is increasingly recognized as a major health care problem, and is found frequently in Pakistani settings. In this article we reviewed published and unpublished data related to the seroepidemiology of HCV infection in Pakistan. For this article, data from 132 published studies and three unpublished data sets published/ presented between the period 1992-2008 were utilized. Data of 1,183,329 individuals were gathered. Blood donors (982,481) and the general population (178,322) constituted the majority of these subjects. The frequency of HCV infection in blood donors and in the general population was 3.0 % (95% CI: 3.0- 3.1) and 4.7 (95% CI: 4.6 -4.8), respectively. The frequency among 6,148 pregnant females was 7.3% (95% CI = 6.7 - 8.0). The frequency in healthy children ranged from 0.4 to 4.1% (95% CI = 1.4 - 2.3). Pakistani HCV serofrequency figures are significantly higher (P < 0.0001) compared to those of the corresponding populations in surrounding countries like India, Nepal, Myanmar, Iran and Afghanistan.
丙型肝炎病毒（HCV）感染日益被视为一个重大的医疗保健问题，在巴基斯坦的环境中经常被发现。在本文中，我们回顾了与巴基斯坦HCV感染血清流行病学相关的已发表和未发表的数据。对于本文，使用了1992年至2008年期间发表的132项研究的数据以及三个未发表的数据集。收集了1,183,329个人的数据。这些受试者中大多数是献血者（982,481人）和普通人群（178,322人）。献血者和普通人群中HCV感染的频率分别为3.0%（95%置信区间：3.0 - 3.1）和4.7%（95%置信区间：4.6 - 4.8）。6,148名孕妇中的感染频率为7.3%（95%置信区间 = 6.7 - 8.0）。健康儿童中的感染频率在0.4%至4.1%之间（95%置信区间 = 1.4 - 2.3）。与印度、尼泊尔、缅甸、伊朗和阿富汗等周边国家的相应人群相比，巴基斯坦的HCV血清频率数据显著更高（P < 0.0001）。
