一项全国代表性样本研究考察了品行障碍、儿童期和成年期创伤事件与创伤后应激障碍之间的关系。

An examination of the relation between conduct disorder, childhood and adulthood traumatic events, and posttraumatic stress disorder in a nationally representative sample.

机构信息

Departments of Community Health Sciences, Psychiatry, and Family Social Sciences, University of Manitoba, S113-750 Bannatyne Avenue, Winnipeg, Manitoba, R3E 0W5, Canada.

出版信息

J Psychiatr Res. 2011 Dec;45(12):1564-72. doi: 10.1016/j.jpsychires.2011.08.005. Epub 2011 Sep 7.

Abstract

BACKGROUND

Clinical data has indicated that exposure to trauma and meeting diagnostic criteria for posttraumatic stress disorder (PTSD) are common among individuals with a history of conduct disorder. However, these relationships have not been adequately examined in a population-based sample.

METHODS

Data were drawn from Wave 2 of the U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) collected in 2004-2005 (n = 34,653, response rate = 86.7%). Multivariate logistic regression analyses were conducted to examine relations between conduct disorder, traumatic life events, and PTSD in the full sample, and separately for males and females.

RESULTS

The main findings indicate that childhood maltreatment was associated with conduct disorder (Adjusted Odds Ratio [AOR] ranging from 2.4 to 4.7) after adjustment for sociodemographic variables. Additionally, respondents with a history of conduct disorder compared to respondents without conduct disorder were more likely to report experiencing any traumatic event (AOR = 2.7, 95% CI = 2.0-3.6) and PTSD (AOR = 2.2, 95% CI = 1.8-2.7) after adjusting for sociodemographic variables. Although sex differences were noted, conduct disorder was associated with the greatest odds of assaultive violence for males and females. The majority of individuals (72.9%) diagnosed with both conduct disorder and PTSD developed conduct disorder symptoms before PTSD symptoms.

CONCLUSIONS

Results of this study provide the first known sex-stratified examination of the relationship between conduct disorder, traumatic events, and PTSD in a large, population-based sample of adults and are consistent with clinical impressions. Policy and clinical implications are discussed.

摘要

背景

临床数据表明,创伤暴露和符合创伤后应激障碍(PTSD)的诊断标准在有品行障碍病史的个体中很常见。然而,这些关系在基于人群的样本中尚未得到充分研究。

方法

数据来自于 2004-2005 年美国国家酒精与相关条件流行病学调查(NESARC)的第 2 波(n=34653,应答率 86.7%)。采用多元逻辑回归分析,在全样本中以及男性和女性中分别检验品行障碍、创伤性生活事件与 PTSD 之间的关系。

结果

主要发现表明,在调整社会人口学变量后,儿童期虐待与品行障碍有关(调整后的优势比 [AOR] 范围为 2.4 至 4.7)。此外,与没有品行障碍的受访者相比,有品行障碍病史的受访者更有可能报告经历过任何创伤性事件(AOR=2.7,95%CI=2.0-3.6)和 PTSD(AOR=2.2,95%CI=1.8-2.7),在调整社会人口学变量后。尽管存在性别差异,但品行障碍与男性和女性的攻击暴力风险最高。大多数(72.9%)同时被诊断为品行障碍和 PTSD 的个体在出现 PTSD 症状之前出现了品行障碍症状。

结论

这项研究的结果提供了已知的首个在大样本、基于人群的成年人群体中对品行障碍、创伤事件和 PTSD 之间关系的性别分层研究,与临床印象一致。讨论了政策和临床意义。

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