Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Fundació Sant Joan de Déu, Barcelona, Spain.
Cancer Lett. 2011 Dec 15;312(1):73-81. doi: 10.1016/j.canlet.2011.08.004. Epub 2011 Aug 17.
Neuroblastic tumors (NBT) are composed by neuroblasts and Schwannian-like stroma. The origin of these two cell subtypes remains unclear. In this study, we describe, a neuroblastic-like subpopulation in neuroblastoma (NB) coexpressing GD2 and S100A6, neuroblastic and glial lineage markers respectively. The GD2(+)/S100A6(+) neuroblastic subpopulation was found to be enriched in low risk NB, distributed around the perivascular niche. Some stromal bundles showed GD2(+)/S100A6 costaining. Metastatic bone marrow specimens also showed GD2(+)/S100A6(+) cells. During in vitro retinoic acid induced differentiation of NB cell lines, rare GD2(+)/S100A6 neuroblatic cells appeared. We conclude that GD2(+)/S100A6(+) neuroblasts may represent a tumoral glial precursor subpopulation in NBT.
神经母细胞瘤（NBT）由神经母细胞和许旺氏样基质组成。这两种细胞亚型的起源尚不清楚。在这项研究中，我们描述了神经母细胞瘤（NB）中一种表达 GD2 和 S100A6 的神经母细胞样亚群，分别为神经母细胞和神经胶质谱系标志物。发现 GD2(+)/S100A6(+)神经母细胞亚群在低风险 NB 中富集，分布在血管周围龛位周围。一些基质束显示出 GD2(+)/S100A6 共染色。转移性骨髓标本也显示出 GD2(+)/S100A6(+)细胞。在体外视黄酸诱导 NB 细胞系分化过程中，出现了罕见的 GD2(+)/S100A6 神经母细胞。我们得出结论，GD2(+)/S100A6(+)神经母细胞可能代表 NBT 中的肿瘤神经胶质前体细胞亚群。
