一系列 1,2-苯并异噻唑-3(2H)-酮衍生物的抗真菌活性。
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives.
机构信息
Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
出版信息
Bioorg Med Chem. 2011 Oct 1;19(19):5782-7. doi: 10.1016/j.bmc.2011.08.029. Epub 2011 Aug 22.
PMID:21903403
Abstract
A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.
摘要
报道了一系列基于 1,2-苯并异噻唑-3(2H)-酮骨架的广谱抗真菌剂。初步的构效关系研究表明，杂环、甲基和苯基的存在对于最佳抗真菌活性的表现至关重要。
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