Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, India.
Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):745-56. doi: 10.1093/abbs/gmr079. Epub 2011 Sep 7.
The non-canonical Wnt/Ca(2+) signaling cascade is less characterized than their canonical counterpart, the Wnt/β-catenin pathway. The non-canonical Wnt signaling pathways are diverse, defined as planer cell polarity pathway, Wnt-RAP1 signaling pathway, Wnt-Ror2 signaling pathway, Wnt-PKA pathway, Wnt-GSK3MT pathway, Wnt-aPKC pathway, Wnt-RYK pathway, Wnt-mTOR pathway, and Wnt/calcium signaling pathway. All these pathways exhibit a considerable degree of overlap between them. The Wnt/Ca(2+) signaling pathway was deciphered as a crucial mediator in development. However, now there is substantial evidence that the signaling cascade is involved in many other molecular phenomena. Many aspects of Wnt/Ca(2+) pathway are yet enigmatic. This review will give a brief overview of the fundamental and evolving concepts of the Wnt/Ca(2+) signaling pathway.
非经典 Wnt/Ca（2+）信号级联比经典的 Wnt/β-连环蛋白途径的特征不那么明显。非经典 Wnt 信号通路多种多样，定义为平面细胞极性途径、Wnt-RAP1 信号通路、Wnt-Ror2 信号通路、Wnt-PKA 途径、Wnt-GSK3MT 途径、Wnt-aPKC 途径、Wnt-RYK 途径、Wnt-mTOR 途径和 Wnt/钙信号通路。所有这些途径之间都存在相当程度的重叠。Wnt/Ca（2+）信号通路被揭示为发育过程中的关键介质。然而，现在有大量证据表明，该信号级联参与了许多其他分子现象。Wnt/Ca（2+）途径的许多方面仍然是谜。本综述将简要概述 Wnt/Ca（2+）信号通路的基本和不断发展的概念。
