USC INRA 2017, Microbiologie de l'Environnement, EA 956, Université de Caen, France.
Laboratoire de Microbiologie du Froid Signaux et Micro-Environnement (LMDF-SME), UPRES EA4312, Université de Rouen, France.
Microbiology (Reading). 2011 Nov;157(Pt 11):3001-3013. doi: 10.1099/mic.0.053314-0. Epub 2011 Sep 8.
Enterococcus faecalis is a ubiquitous bacterium that is capable of surviving in a broad range of natural environments, including the human host, as either a natural commensal or an opportunistic pathogen involved in severe hospital-acquired infections. How such opportunistic pathogens cause fatal infections is largely unknown but it is likely that they are equipped with sophisticated systems to perceive external signals and interact with eukaryotic cells. Accordingly, being partially exposed at the cell exterior, some surface-associated proteins are involved in several steps of the infection process. Among them are lipoproteins, representing about 25 % of the surface-associated proteins, which could play a major role in bacterial virulence processes. This review focuses on the identification of 90 lipoprotein-encoding genes in the genome of the E. faecalis V583 clinical strain and their putative roles, and provides a transcriptional comparison of microarray data performed in environmental conditions including blood and urine. Taken together, these data suggest a potential involvement of lipoproteins in E. faecalis virulence, making them serious candidates for vaccine production.
粪肠球菌是一种无处不在的细菌，能够在广泛的自然环境中生存，包括人类宿主，作为一种天然共生菌或机会性病原体，参与严重的医院获得性感染。这种机会性病原体如何引起致命感染在很大程度上是未知的，但它们很可能配备了复杂的系统来感知外部信号并与真核细胞相互作用。因此，部分暴露在细胞外部的一些表面相关蛋白参与了感染过程的几个步骤。其中包括脂蛋白，占表面相关蛋白的约 25%，它们可能在细菌毒力过程中发挥重要作用。本综述重点介绍了在粪肠球菌 V583 临床株基因组中鉴定出的 90 个脂蛋白编码基因及其可能的作用，并提供了在血液和尿液等环境条件下进行微阵列数据分析的转录比较。总之，这些数据表明脂蛋白可能参与了粪肠球菌的毒力，使它们成为疫苗生产的重要候选者。
