Moran Gary P, Coleman David C, Sullivan Derek J
Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, Dublin 2, Ireland.
Int J Microbiol. 2012;2012:205921. doi: 10.1155/2012/205921. Epub 2011 Sep 4.
Candida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection models. Comparison of the genomes of the two species has revealed that they are very similar although there are some significant differences, largely due to the expansion of virulence-related gene families (e.g., ALS and SAP) in C. albicans, and increased levels of pseudogenisation in C. dubliniensis. Comparative global gene expression analyses have also been used to investigate differences in the ability of the two species to tolerate environmental stress and to produce hyphae, two traits that are likely to play a role in the lower virulence of C. dubliniensis. Taken together, these data suggest that C. dubliniensis is in the process of undergoing reductive evolution and may have become adapted for growth in a specialized anatomic niche.
白色念珠菌和都柏林念珠菌是高度相关的致病酵母物种。然而，白色念珠菌在人类感染中更为普遍，并且在广泛的感染模型中已显示出更强的致病性。对这两个物种的基因组进行比较后发现，它们非常相似，尽管存在一些显著差异，这主要是由于白色念珠菌中毒力相关基因家族（如ALS和SAP）的扩增，以及都柏林念珠菌中假基因化水平的提高。比较全基因组基因表达分析也被用于研究这两个物种耐受环境压力和产生菌丝能力的差异，这两个特征可能在都柏林念珠菌较低的毒力中起作用。综合这些数据表明，都柏林念珠菌正处于经历简化进化的过程中，并且可能已经适应了在特定解剖生态位中的生长。
