在年轻男性中，总睾酮与前列腺癌的差异比游离睾酮更为密切相关。

Total testosterone in young men is more closely associated than free testosterone with prostate cancer disparities.

机构信息

Department of Anthropology, MSC01-1040, 1 University of New Mexico, Albuquerque, NM 87131, USA.

出版信息

Ther Adv Urol. 2011 Jun;3(3):99-106. doi: 10.1177/1756287211405706.

DOI:10.1177/1756287211405706

PMID:21904566

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3159397/

Abstract

INTRODUCTION

Early adulthood has been suggested as the most relevant time to determine the influence of testosterone on prostate carcinogenesis. For a more detailed assessment of this hypothesis, the present study examined whether serum total or free testosterone in young men was more closely associated with prostate cancer disparities.

METHODS

A literature search was conducted for studies that reported both total and free testosterone levels for population samples of young men, along with prostate cancer incidences for the populations from which study populations were sampled. A previously developed analytical method was used to standardize the hormone levels of 19 population samples gathered from nine studies, and these standardized values were compared with disparities in prostate cancer incidence.

RESULTS

Population differences in total testosterone levels were significantly associated with prostate cancer disparities, r = 0.833, p = 0.001, as were population differences in free testosterone, r = 0.661, p = 0.027. After controlling for age differences, total and free testosterone remained associated with prostate cancer disparities, partial r = 0.888, p < 0.001, and partial r = 0.657, p = 0.039, respectively. A marginally significant difference existed in the strength of relationships between total and free testosterone with respect to prostate cancer disparities, with total testosterone exhibiting a stronger association, T(2) = 1.573, p = 0.077.

CONCLUSIONS

Across analyses, total testosterone demonstrated a more robust relationship than free testosterone with cancer disparities, which may suggest that total testosterone is the more sensitive biomarker for evaluating androgenic stimulation of the prostate gland.

摘要

简介

青年期被认为是确定睾丸酮对前列腺癌发生影响的最相关时期。为了更详细地评估这一假说，本研究检测了年轻男性的血清总睾酮或游离睾酮是否与前列腺癌差异更密切相关。

方法

对报告了年轻男性人群样本的总睾酮和游离睾酮水平以及从研究人群采样的人群的前列腺癌发病率的研究进行了文献检索。使用先前开发的分析方法对来自 9 项研究的 19 个人群样本的激素水平进行了标准化，并且将这些标准化值与前列腺癌发病率的差异进行了比较。

结果

总睾酮水平的人群差异与前列腺癌差异显著相关，r=0.833，p=0.001，游离睾酮的人群差异也与前列腺癌差异显著相关，r=0.661，p=0.027。在控制年龄差异后，总睾酮和游离睾酮仍与前列腺癌差异相关，偏相关 r=0.888，p<0.001，和偏相关 r=0.657，p=0.039。总睾酮和游离睾酮与前列腺癌差异之间的关系强度存在边际显著差异，总睾酮表现出更强的相关性，T(2)=1.573，p=0.077。