高效铜催化的芳基卤化物与炔基羧酸的脱羧偶联反应。
Highly effective copper-catalyzed decarboxylative coupling of aryl halides with alkynyl carboxylic acids.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, P. R. China.
出版信息
Org Biomol Chem. 2011 Oct 21;9(20):6938-42. doi: 10.1039/c1ob05969f. Epub 2011 Sep 8.
PMID:21904730
Abstract
We have developed a highly effective copper-catalyzed decarboxylative coupling of alkynylcarboxylic acids with various aryl and alkyl halides at 2 mol% loading of copper. This method is simple, economical and practical for the synthesis of disubstituted alkyne compounds.
摘要
我们开发了一种高效的铜催化脱羧偶联反应，能够使各种芳基和烷基卤化物与炔基羧酸在 2 摩尔%的铜负载量下反应。该方法简单、经济且实用，可用于合成二取代炔烃化合物。
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