铜催化的炔基羧酸酯与 1,1-二溴-1-烯烃的脱羧偶联反应。
Copper-catalyzed decarboxylative coupling of alkynyl carboxylates with 1,1-dibromo-1-alkenes.
机构信息
Anhui Province Key Laboratory of Biomass Clean Energy, Collaborative Innovative Center of Chemistry for Energy Materials, and Department of Chemistry, University of Science and Technology of China, Hefei 230026, PR China.
出版信息
J Org Chem. 2013 May 3;78(9):4551-7. doi: 10.1021/jo400616r. Epub 2013 Apr 15.
A copper-catalyzed decarboxylative coupling reaction of potassium alkynyl carboxylates with 1,1-dibromo-1-alkenes was developed for the synthesis of unsymmetrical 1,3-diyne and 1,3,5-triyne derivatives. Diverse aryl, alkenyl, alkynyl, and alkyl substituted 1,1-dibromo-1-alkenes can react smoothly with aryl and alkyl substituted propiolates to produce unsymmetrical 1,3-diynes and 1,3,5-triynes with high selectivity and good functional group compatibility.
发展了一种铜催化的钾炔基羧酸酯与 1,1-二溴-1-烯烃的脱羧偶联反应，用于合成不对称的 1,3-二炔和 1,3,5-三炔衍生物。各种芳基、烯基、炔基和烷基取代的 1,1-二溴-1-烯烃可以与芳基和烷基取代的丙炔酸酯顺利反应，以高选择性和良好的官能团兼容性生成不对称的 1,3-二炔和 1,3,5-三炔。
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