MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, and Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, United Kingdom.
Neurotherapeutics. 2011 Oct;8(4):650-8. doi: 10.1007/s13311-011-0065-x.
Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.
中枢神经系统脱髓鞘后髓鞘的再生（再髓鞘化）对于恢复跳跃传导和防止轴突丢失很重要。在多发性硬化症中，再髓鞘化不足导致轴突的不可逆转退化和相关的临床衰退。因此，一种促进再髓鞘化的再生策略可能会保护轴突并改善多发性硬化症的症状。我们重点介绍了最近关于影响内源性再髓鞘化的因素的研究，以及可能被考虑用于增强中枢神经系统再髓鞘化的潜在有前途的药理靶点。
