Chair and Division of Cardiology, II Faculty of Medicine, University La Sapienza, Sant'Andrea Hospital, Rome, Italy.
Clin Cardiol. 2011 Sep;34(9):560-6. doi: 10.1002/clc.20937.
The Evaluation of Final Feasible Effect of Ultra Control Training and Sensitization (EFFECTUS) study is aimed at implementing global cardiovascular (CV) risk management in Italy.
To evaluate the impact of diabetes mellitus (DM) on attitudes and preferences for clinical management of global CV risk among physicians treating diabetic or nondiabetic patients.
Involved physicians were asked to submit data into a study-designed case-report form, covering the first 10 adult outpatients consecutively seen in May 2006. All available clinical data were centrally analyzed for global CV risk assessment and CV risk profile characterization. Patients were stratified according to the presence or absence of DM.
Overall, 1078 physicians (27% female, ages 50 ± 7 y) collected data of 9904 outpatients (46.5% female, ages 67 ± 9 y), among whom 3681 (37%) had a diagnosis of DM at baseline. Diabetic patients were older and had higher prevalence of obesity, hypertension, dyslipidemia, and associated CV diseases than nondiabetic individuals (P<0.001). They had higher systolic blood pressure, total cholesterol, triglycerides, and creatinine levels, but lower high-density lipoprotein cholesterol levels than nondiabetic patients (P<0.001). Higher numbers of blood pressure and lipid-lowering drugs and antiplatelet agents were used in diabetic than in nondiabetic patients (P<0.001).
The EFFECTUS study confirmed higher CV risk and more CV drug prescriptions in diabetic than in nondiabetic patients. Presence of DM at baseline significantly improved clinical data collection. Such an approach, however, was not paralleled by a better control of global CV risk profile, which was significantly worse in the former than in the latter group.
超控训练和敏化效果评估（EFFECTUS）研究旨在意大利实施全球心血管（CV）风险管理。
评估糖尿病（DM）对治疗糖尿病或非糖尿病患者的医生对全球 CV 风险临床管理的态度和偏好的影响。
要求参与的医生提交数据到研究设计的病例报告表中，涵盖 2006 年 5 月连续就诊的前 10 位成年门诊患者。所有可用的临床数据均进行集中分析，以评估全球 CV 风险和 CV 风险特征。根据是否存在 DM 将患者分层。
共有 1078 名医生（27%为女性，年龄 50 ± 7 岁）收集了 9904 名门诊患者（46.5%为女性，年龄 67 ± 9 岁）的数据，其中 3681 名（37%）在基线时患有 DM。与非糖尿病患者相比，糖尿病患者年龄较大，且肥胖、高血压、血脂异常和相关 CV 疾病的患病率更高（P<0.001）。他们的收缩压、总胆固醇、甘油三酯和肌酐水平较高，但高密度脂蛋白胆固醇水平较低（P<0.001）。与非糖尿病患者相比，糖尿病患者使用的降压药和降脂药以及抗血小板药物数量更多（P<0.001）。
EFFECTUS 研究证实，与非糖尿病患者相比，糖尿病患者的 CV 风险更高，CV 药物处方更多。基线时存在 DM 显著改善了临床数据的收集。然而，这种方法并没有带来更好的全球 CV 风险状况的控制，在前者中明显比后者更差。
