AmpliPhi Biosciences Corp., Colworth Science Park, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Expert Rev Anti Infect Ther. 2011 Sep;9(9):775-85. doi: 10.1586/eri.11.90.
The use of bacteriophages (phages) to treat bacterial infections, known as phage therapy, has a history substantially longer than that of antibiotics, yet these drugs have been the treatment of choice in the West for over 60 years owing to efficacy, low toxicity and ease of production. Bacteria are becoming increasingly resistant to antibiotics while efforts to discover new agents have drastically reduced. Phages have co-evolved with their hosts over billions of years and have acquired mechanisms to counter bacterial defences such as extracellular biofilm production, which severely reduces the effectiveness of conventional antibiotics. Recent animal and human trials show phages to be safe, well-tolerated agents with a bright future as an alternative to chemical agents.
噬菌体（phages）被用于治疗细菌感染，这种疗法被称为噬菌体疗法，其历史比抗生素长得多，但由于疗效高、毒性低、易于生产，这些药物在西方已经成为首选治疗方法 60 多年。随着发现新药物的努力大大减少，细菌对抗生素的耐药性越来越强。噬菌体与它们的宿主在数十亿年的时间里共同进化，并获得了对抗细菌防御的机制，如产生细胞外生物膜，这严重降低了传统抗生素的有效性。最近的动物和人体试验表明，噬菌体是安全的、耐受良好的药物，作为化学药物的替代品具有广阔的前景。
