Laboratoire de Parasitologie-Mycologie, Groupe Hospitalier Chenevier-Mondor, France.
Med Mycol. 2012 Apr;50(3):305-9. doi: 10.3109/13693786.2011.605810. Epub 2011 Sep 12.
We report the first human case of dermatophytosis caused by Trichophyton bullosum in a 21-year-old male who had a skin lesion located on his forearm. The dermatophyte was isolated in culture and further identified by sequence analysis of internal transcripted spacer regions. The species T. bullosum is a zoophilic dermatophyte rarely isolated from the coat of horses in Africa and Asia. In the present case, it was probably transmitted by contact with an infected donkey in a rural area in France. Antifungal therapy led to remission of the lesion in the patient after 2 months of treatment. T. bullosum ITS region sequences were closely related to those of the African species of Arthroderma benhamiae and grouped in a zoophilic cluster with Trichophyton verrucosum, T. erinacei and the Trichophyton anamorph of A. benhamiae (zoophilic species of the T. mentagrophytes complex). Systematic molecular identification could contribute to an accurate identification of this unusual species.
我们报告了首例由 Bullosum 絮状表皮癣菌引起的人类皮肤癣菌病，患者为 21 岁男性，前臂有皮肤损伤。该真菌通过培养进行分离，并通过内部转录间隔区序列分析进一步鉴定。种 Bullosum 絮状表皮癣菌是一种亲动物性的皮肤癣菌，很少从非洲和亚洲的马毛中分离出来。在本病例中，它可能是通过与法国农村地区受感染的驴接触而传播的。经过 2 个月的治疗，抗真菌治疗使患者的皮损得到缓解。Bullosum 絮状表皮癣菌 ITS 区序列与非洲 Arthroderma benhamiae 种的序列密切相关，与 Trichophyton verrucosum、T. erinacei 和 Arthroderma benhamiae 的 Trichophyton 无性型（亲动物性的 T. mentagrophytes 复合体）一起组成一个亲动物性聚类。系统分子鉴定有助于对这种不寻常的物种进行准确鉴定。
