Rapp J P, Wang S M, Dene H
Department of Medicine, Medical College of Ohio, Toledo 43699.
Am J Hypertens. 1990 May;3(5 Pt 1):391-6. doi: 10.1093/ajh/3.5.391.
The cosegregation of renin alleles and blood pressure was evaluated in segregating populations derived from inbred Dahl salt hypertension sensitive (S) and inbred Dahl salt hypertension resistant (R) rats. The populations were raised on high salt diet (8% NaCl). In F2 and F1 X S populations, there was a significant positive gene-dosage relationship between the S-rat renin allele and blood pressure. In contrast, no such relationship was seen in the F1 X R population. Since in the F1 X R population the genetic background is strongly influenced by genes from the R rat (75% R, 25% S), the result is interpreted to mean that genes at other (unidentified) loci modify the blood pressure effect of the S-rat renin allele.
在由近交系达利盐敏感型高血压（S）大鼠和近交系达利盐抵抗型高血压（R）大鼠产生的分离群体中，对肾素等位基因与血压的共分离情况进行了评估。这些群体以高盐饮食（8%氯化钠）饲养。在F2和F1×S群体中，S大鼠肾素等位基因与血压之间存在显著的正基因剂量关系。相比之下，在F1×R群体中未观察到这种关系。由于在F1×R群体中，遗传背景受到来自R大鼠基因的强烈影响（75%R，25%S），因此该结果被解释为意味着其他（未确定的）位点的基因会改变S大鼠肾素等位基因对血压的影响。
