Laboratorio de Genetica del Comportamiento, Fundación Instituto Leloir, Instituto de Investigaciones Bioquımicas de Buenos Aires, CONICET, Av. Patricias Argentinas 435 - Ciudad Autónoma de Buenos Aires, (C1405BWE) Argentina.
Int Rev Neurobiol. 2011;99:107-38. doi: 10.1016/B978-0-12-387003-2.00005-7.
Over the years it has become clear that the biological clock acts at different levels, ranging from the control of gene expression, protein stability, or subcellular localization of key proteins, to the fine tuning of network properties and modulation of input signals, ultimately ensuring that the organism will be best synchronized to a changing environment at the physiological and behavioral levels. The purpose of this chapter is to discuss the circadian control of clock outputs, spanning the most immediate ones within pacemaker neurons (i.e., membrane excitability, release of neurotransmitters, structural changes) to the circadian modulation of different behaviors (locomotor activity, learning and memory, social interaction), with a focus on the examples that shed light on the surprising degree of plasticity that characterizes the underlying circuits.
多年来，人们已经清楚地认识到生物钟在不同层面起作用，范围从基因表达、蛋白质稳定性或关键蛋白质的亚细胞定位的控制，到网络特性的微调以及输入信号的调制，最终确保生物体在生理和行为水平上与不断变化的环境最佳同步。本章的目的是讨论生物钟输出的节律控制，涵盖从起搏神经元内最直接的输出（即膜兴奋性、神经递质释放、结构变化）到不同行为的节律调制（运动活性、学习和记忆、社交互动），重点介绍阐明其潜在电路具有惊人可塑性的示例。
