Department Molecular Cellbiology, Dermatology Center Buxtehude, Elbekliniken Stade/Buxtehude, Klinikum Buxtehude, Buxtehude, Germany.
Prog Biophys Mol Biol. 2011 Dec;107(3):473-6. doi: 10.1016/j.pbiomolbio.2011.08.008. Epub 2011 Sep 3.
Solar and artificial (sunbed) UV-exposure is the main risk factor for the development of epithelial skin cancer (basal cell carcinoma, BCC, and squamous cell carcinoma, SCC) as well for malignant melanoma (MM). UV exposure in childhood and adolescence is especially important. Therefore, adequate methods of primary prevention have continuously to be used and to be developed further to target these age-groups in order to reduce the risks of intensive UV-exposure. Primary prevention can effectively be combined with secondary prevention (early detection, screening) to reduce the burden of skin cancer and to decrease incidence, morbidity and mortality.
阳光和人工(太阳床)紫外线照射是上皮皮肤癌(基底细胞癌、BCC 和鳞状细胞癌、SCC)以及恶性黑素瘤(MM)发展的主要危险因素。儿童和青少年时期的紫外线照射尤其重要。因此,必须不断使用和进一步开发适当的初级预防方法,以针对这些年龄组,降低高强度紫外线照射的风险。初级预防可以与二级预防(早期发现、筛查)有效结合,以减少皮肤癌的负担,降低发病率、患病率和死亡率。