Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Neuroscience. 2011 Dec 15;198:3-18. doi: 10.1016/j.neuroscience.2011.08.051. Epub 2011 Aug 27.
In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses, cells, and circuits can be reliably studied. This review attempts to summarize some of the key advances in this broad area, focusing on dopaminergic modulation of intrinsic excitability and synaptic plasticity in canonical microcircuits in the striatum as well as recent work suggesting that there are neuronal assemblies within the striatum devoted to particular types of computation and possibly action selection.
近年来，人们在理解纹状体和多巴胺在动作选择中的作用方面取得了很大进展。新的动物模型的出现和用于成像和刺激特定神经元群体的光学技术的发展为可靠地研究已鉴定的突触、细胞和回路提供了手段。本综述试图总结这一广泛领域的一些关键进展，重点介绍纹状体中经典微回路中多巴胺能对内在兴奋性和突触可塑性的调制，以及最近的工作表明，纹状体中存在专门用于特定类型计算和可能的动作选择的神经元集合。
