Matityahu Lior, Hobel Zachary B, Berkowitz Noa, Malgady Jeffrey M, Gilin Naomi, Plotkin Joshua L, Goldberg Joshua A
Department of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, 9112102, Israel.
Department of Neurobiology and Behavior, Center for Nervous System Disorders, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, 11794, USA.
bioRxiv. 2024 Dec 11:2024.11.03.621726. doi: 10.1101/2024.11.03.621726.
Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.
纹状体胆碱能中间神经元（CINs）激活多巴胺轴突上的烟碱型乙酰胆碱受体，以扩大多巴胺释放的范围。在此，我们表明CINs的同步激活通过类似机制诱导并扩大了局部血清素释放的范围。在类强迫症行为小鼠模型的高胆碱能纹状体中，这一过程被放大，这表明CINs是健康和病理纹状体中血清素水平的关键调节因子。
