Brain Repair Group, Schools of Biosciences and Medicine, Cardiff University, Cardiff, Wales, UK.
Int Rev Neurobiol. 2011;98:483-508. doi: 10.1016/B978-0-12-381328-2.00017-1.
In experimental rats, mice, and monkeys, transplantation of embryonic striatal cells into the striatum can repair the damage and alleviate the functional deficits caused by striatal lesions. Such strategies have been translated to striatal repair by cell transplantation in small numbers of patients with progressive genetic striatal degeneration in Huntington's disease. In spite of some encouraging preliminary data, the clinical results are to date neither as reliable nor as compelling as the broad extend of recovery observed in the animal models across motor, cognitive, and skill and habit learning domains. Strategies to achieve immediate and long-term improvements in the clinical applications include identifying and limiting the causes of complications, standardization and quality control of preparation and delivery, appropriate patient selection to match the cellular repair to specific profiles of cell loss and degeneration in individual patients and different neurodegenerative diseases, and improving the availability of alternative sources of donor cells and tissues.
在实验大鼠、小鼠和猴子中，将胚胎纹状体细胞移植到纹状体中可以修复损伤并减轻纹状体损伤引起的功能缺陷。这些策略已被转化为通过细胞移植来修复纹状体，在少数亨廷顿病进行性遗传纹状体变性患者中进行了尝试。尽管有一些令人鼓舞的初步数据，但迄今为止，临床结果既不如动物模型中观察到的那样广泛，也不如运动、认知、技能和习惯学习领域那样可靠。实现临床应用中即刻和长期改善的策略包括识别和限制并发症的原因、准备和输送的标准化和质量控制、根据特定患者和不同神经退行性疾病中细胞丢失和变性的特定模式选择合适的患者，以及改善供体细胞和组织的可用性。
