Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Am J Pathol. 2011 Nov;179(5):2152-6. doi: 10.1016/j.ajpath.2011.07.021. Epub 2011 Sep 9.
Parkinson's disease (PD) is characterized by α-synuclein-containing Lewy bodies (LBs) and loss of melanized neurons in the substantia nigra (SN). Recently, a link between apolipoprotein E (ApoE) expression, α-synuclein aggregation, and neurodegeneration was suggested. Here, we report on ApoE expression appearing in melanized neurons of the SN and in LBs in both PD and incidental LB disease cases. Interestingly, increased expression of the low-density lipoprotein receptor-related protein 1 (the receptor for ApoE) was also observed in incidental LB disease and PD. Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis.
帕金森病（PD）的特征是含有α-突触核蛋白的路易体（LB）和黑质（SN）中黑色素神经元的丧失。最近，有人提出载脂蛋白 E（ApoE）表达、α-突触核蛋白聚集和神经退行性变之间存在联系。在这里，我们报告了 ApoE 表达出现在 SN 中的黑色素神经元和 PD 和偶发性 LB 疾病病例中的 LB 中。有趣的是，在偶发性 LB 疾病和 PD 中也观察到低密度脂蛋白受体相关蛋白 1（ApoE 的受体）的表达增加。我们的数据表明，SN 中黑色素神经元的脂蛋白稳态/信号转导改变是 PD 发病机制中的早期事件。
