Department of Biosciences, Federal University of São Paulo (UNIFESP), Santos, SP, Brazil.
Behav Brain Res. 2012 Jan 1;226(1):50-5. doi: 10.1016/j.bbr.2011.08.044. Epub 2011 Sep 3.
Serotonin in the lateral septum has been implicated in the modulation of defense and hence in anxiety. However, it deserves investigation how changes in 5-HT-mechanisms in this area modulate defensive responses associated with specific subtypes of anxiety disorders. We evaluated the effects of intra-dorsolateral septum (DLS) injections of the preferential 5-HT(2A) receptor agonist DOI (8 and 16nmol), the 5-HT(2C) selective agonist MK-212 (0.1 and 1nmol) and the preferential 5-HT(2A) antagonist ketanserin (10 and 20nmol) in rats exposed to the elevated T-maze (ETM), a model which allows the measurement of two defensive responses: inhibitory avoidance and escape. These responses have been respectively related to generalized anxiety and panic disorder. All animals were tested in an open-field after the ETM for locomotor activity assessments. Results showed that intra-DLS DOI increased avoidance latencies, an anxiogenic effect. MK and ketanserin were without effect. Also, none of the drugs administered affected the escape performance. Ketanserin blocked the anxiogenic effect caused by DOI. No changes to locomotion were observed. The data suggests that DLS 5-HT(2A) receptors are involved in the control of inhibitory avoidance and that a failure in this mechanism may be of importance to the physiopathology of generalized anxiety.
外侧隔核中的血清素已被牵涉到防御的调节中，因此与焦虑有关。然而，值得研究的是，该区域 5-HT 机制的变化如何调节与特定焦虑障碍亚型相关的防御反应。我们评估了内侧背外侧隔核（DLS）注射 5-HT（2A）受体激动剂 DOI（8 和 16nmol）、5-HT（2C）选择性激动剂 MK-212（0.1 和 1nmol）和 5-HT（2A）选择性拮抗剂酮舍林（10 和 20nmol）对暴露于高架 T 迷宫（ETM）的大鼠的影响，ETM 是一种允许测量两种防御反应的模型：抑制性回避和逃避。这些反应分别与广泛性焦虑症和恐慌症有关。所有动物在 ETM 后都在开阔场中进行运动活动评估。结果表明，内侧 DLS DOI 增加了回避潜伏期，这是一种焦虑作用。MK 和酮舍林没有效果。此外，给予的任何药物都没有影响逃避表现。酮舍林阻断了 DOI 引起的焦虑作用。未观察到运动的变化。数据表明，DLS 5-HT（2A）受体参与抑制性回避的控制，并且该机制的失败可能对广泛性焦虑症的病理生理学很重要。
