Khakpai Fatemeh, Nasehi Mohammad, Haeri-Rohani Ali, Eidi Akram, Zarrindast Mohammad Reza
Institute for Cognitive Science Studies (ICSS), Tehran, Iran.
Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Garmsar Branch, Semnan, Iran.
Basic Clin Neurosci. 2013 Winter;4(1):5-23.
The Cholinergic and GABAergic fibers of the medial septal/diagonal band of Broca (MS/ DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitter systems including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and other systems-mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus.
内侧隔区/布罗卡斜角带（MS/DB）区域的胆碱能和γ-氨基丁酸能纤维投射至海马体，构成隔-海马通路，该通路已被证实对学习和记忆起作用。此外，海马体与隔区存在双向连接，从而实现胆碱能输入的自我调节。隔区和海马体神经元的活动受多种神经递质系统调节，包括来自内嗅皮质的谷氨酸能神经元、来自中缝核的5-羟色胺能纤维、来自腹侧被盖区（VTA）的多巴胺能神经元、来自结节乳头体核的组胺能细胞以及来自蓝斑（LC）的肾上腺素能纤维。因此，MS/DB中谷氨酸能、5-羟色胺能及其他系统介导的传递变化可能会影响海马体中的胆碱能或γ-氨基丁酸能传递。
