Central Veterinary Institute, Wageningen UR, P.O. Box 65, 8200 AB Lelystad, The Netherlands.
Fish Shellfish Immunol. 2011 Dec;31(6):1211-7. doi: 10.1016/j.fsi.2011.08.004. Epub 2011 Sep 1.
Viral interleukin 10 (IL-10) like open reading frames have been identified in several pox- and herpesviruses, including the fish herpesviruses Anguillid herpesvirus 1 (AngHV-1) and Cyprinid herpesvirus 3 (CyHV-3). European eel (Anguilla anguilla) IL-10 was sequenced, in order to compare European eel and common carp (Cyprinus carpio) IL-10 with their alloherpesviral counterparts. Homology between the virus and host IL-10 amino acid sequences is low, which is confirmed by phylogenetic analysis. However, the three dimensional structures of the fish and alloherpesviral IL-10 proteins as predicted by modeling are highly similar to human IL-10. Closely related AngHV-1 and CyHV-3 are expected to have obtained their viral IL-10 genes independently in the course of coexistence with their respective hosts. The presence and structural conservation of these alloherpesviral IL-10 genes suggest that they might play an important role in the evolution of pathogenesis.
病毒白细胞介素 10（IL-10）类似开放阅读框已在几种痘病毒和疱疹病毒中被鉴定，包括鱼类疱疹病毒鳗鲡疱疹病毒 1（AngHV-1）和鲤鱼疱疹病毒 3（CyHV-3）。为了比较鳗鲡和鲤鱼的白细胞介素 10 与其 alloherpesviral 对应物，对欧洲鳗鲡（Anguilla anguilla）IL-10 进行了测序。病毒和宿主 IL-10 氨基酸序列之间的同源性较低，这通过系统发育分析得到证实。然而，通过建模预测的鱼类和 alloherpesviral IL-10 蛋白的三维结构与人 IL-10 高度相似。密切相关的 AngHV-1 和 CyHV-3 预计在与各自宿主共存的过程中独立获得了其病毒 IL-10 基因。这些 alloherpesviral IL-10 基因的存在和结构保守性表明它们可能在发病机制的进化中发挥重要作用。
