Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China.
Breast Cancer Res Treat. 2010 Aug;122(3):867-71. doi: 10.1007/s10549-010-0739-9. Epub 2010 Jan 19.
Published data on the association between insulin-like growth factor binding protein 3 (IGFBP3) A-202C polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 27 studies including 33,557 cases and 45,254 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with IGFBP3 C allele when all studies were pooled into the meta-analysis (CC vs. AA: OR = 1.06, 95% CI = 1.02-1.11; dominant model: OR = 1.04, 95% CI = 1.00-1.07). In the subgroup analysis by ethnicity, significantly increased risk was found for Caucasians (AC vs. AA: OR = 1.04, 95% CI = 1.00-1.08; CC vs. AA: OR = 1.05, 95% CI = 1.01-1.10; dominant model: OR = 1.04, 95% CI = 1.00-1.08) and Asians (CC vs. AA: OR = 1.35, 95% CI = 1.02-1.78; recessive model: OR = 1.38, 95% CI = 1.05-1.82). When stratified by study design, statistically significantly elevated risk was found among population-based studies (CC vs. AA: OR = 1.06, 95% CI = 1.01-1.11; dominant model: OR = 1.03, 95% CI = 1.00-1.07). In the subgroup analysis by menopausal status, no statistically significantly increased risk was found among premenopausal or postmenopausal women. In conclusion, this meta-analysis suggests that the IGFBP3 C allele is a low-penetrant risk factor for developing breast cancer.
关于胰岛素样生长因子结合蛋白 3（IGFBP3）A-202C 多态性与乳腺癌风险之间的关联，已有发表的数据尚无定论。为了更准确地评估这种关系，进行了荟萃分析。使用粗比值比（OR）和 95%置信区间（CI）来评估它们之间的关联强度。这项荟萃分析共纳入了 27 项研究，包括 33557 例病例和 45254 例对照。总的来说，当所有研究都纳入荟萃分析时，IGFBP3 C 等位基因与乳腺癌风险显著升高相关（CC 与 AA：OR=1.06，95%CI=1.02-1.11；显性模型：OR=1.04，95%CI=1.00-1.07）。按种族亚组分析，在白种人和亚洲人中发现风险显著增加（AC 与 AA：OR=1.04，95%CI=1.00-1.08；CC 与 AA：OR=1.05，95%CI=1.01-1.10；显性模型：OR=1.04，95%CI=1.00-1.08）。按研究设计分层，在基于人群的研究中发现风险显著升高（CC 与 AA：OR=1.06，95%CI=1.01-1.11；显性模型：OR=1.03，95%CI=1.00-1.07）。按绝经状态亚组分析，在绝经前或绝经后妇女中未发现风险显著增加。总之，这项荟萃分析表明，IGFBP3 C 等位基因是乳腺癌发生的低外显率风险因素。
