Cardiac Physiology Section, Systems Biology Center, NHLBI, NIH, Bethesda, MD 20892, USA.
J Mol Cell Cardiol. 2012 Mar;52(3):568-77. doi: 10.1016/j.yjmcc.2011.08.021. Epub 2011 Aug 27.
In this review, the role of S-nitrosylation (SNO) in cardioprotection will be discussed. This review will cover the methodology used to measure SNO levels, and the mechanisms by which SNO serves to modulate cell function and mediate protection. We will also consider whether SNO acts through many targets or whether there are a few key SNO proteins that mediate protection. Issues regarding the percentage of the total protein which is SNO and how this plays a role in the modulation of cell function will also be discussed. The role of nitric oxide synthase uncoupling in cardioprotection will also be addressed. This article is part of a Special Section entitled "Post-translational Modification."
在这篇综述中，将讨论 S-亚硝基化（SNO）在心脏保护中的作用。这篇综述将涵盖用于测量 SNO 水平的方法，以及 SNO 调节细胞功能和介导保护的机制。我们还将考虑 SNO 是否通过许多靶点起作用，还是存在少数关键的 SNO 蛋白来介导保护。关于总蛋白中 SNO 的百分比以及它在调节细胞功能中的作用的问题也将进行讨论。一氧化氮合酶解偶联在心脏保护中的作用也将得到解决。本文是特刊“翻译后修饰”的一部分。
