Linsen-Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan.
Fitoterapia. 2011 Dec;82(8):1249-57. doi: 10.1016/j.fitote.2011.08.016. Epub 2011 Sep 1.
Intestinal α-glucosidase performs a physiologically vital function in the digestive process of dietary carbohydrates. Administration of an α-glucosidase inhibitor may retard the digestion and absorption of carbohydrates. Consequently, the rise in postprandial blood glucose could be suppressed. This study developed a novel technology, called "after flowing through immobilized receptor (AFTIR)," for targeting components in herbal medicines with α-glucosidase-suppressing capability. As a result, we reveal that the AFTIR system is a highly-efficient drug screening platform, capable of purifying and identifying active components with α-glucosidase-suppressing capability in herbal medicines.
肠道 α-葡萄糖苷酶在碳水化合物的消化过程中发挥着重要的生理功能。使用 α-葡萄糖苷酶抑制剂可以减缓碳水化合物的消化和吸收。因此，可以抑制餐后血糖升高。本研究开发了一种名为“固定化受体后流（AFTIR）”的新技术，用于靶向具有 α-葡萄糖苷酶抑制能力的草药成分。结果表明，AFTIR 系统是一种高效的药物筛选平台，能够从草药中分离和鉴定具有 α-葡萄糖苷酶抑制能力的活性成分。
