Ras、ROS 和蛋白毒性应激：微妙的平衡。
Ras, ROS and proteotoxic stress: a delicate balance.
机构信息
Urologic Oncology Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA.
出版信息
Cancer Cell. 2011 Sep 13;20(3):281-2. doi: 10.1016/j.ccr.2011.08.020.
Abstract
Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death.
摘要
Ras 失调的细胞增殖需要活性氧。它们通过维持足够水平的还原型谷胱甘肽和最佳功能的应激反应机制来应对由此产生的蛋白毒性应激而存活。在本期《癌细胞》杂志中，De Raedt 等人确定了一种新的策略，利用这种依赖性来导致细胞死亡。
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