Patel Freddy
Greater London Forensic Medical Practice, Dennis Geffen Health Annexe, St Pancras Gardens, Camley Street, Kings Cross, London NW1 0PP, UK.
J Forensic Leg Med. 2011 Oct;18(7):340-2. doi: 10.1016/j.jflm.2011.06.014. Epub 2011 Jul 13.
Rotenone is a pesticide and a piscicide derived from the derris root. The mechanism for the cytotoxicity is at mitochondrial level affecting cellular respiration. A suicide by rotenone poisoning in an adult is described. An innovative laboratory methodology was developed for the principal requirement of the Coroner to determine a positive or negative result to assist in the investigation of the death. The antemortem concentrations detected were 4.05 ng/ml [0.00405 ppm] in the blood and 0.55 ng/ml [0.00055 ppm] in the serum. Toxicity in human is rare and therefore the interpretation of the toxicology results is complicated by the unavailability of a data bank. The cause of death was attributed to rotenone toxicity based on the circumstantial evidence and expert pathological opinion on a balance of probability acceptable under the Coroners Act 1988 and Coroners Rules 1984 in England and Wales. The forensic clinicopathology of rotenone toxicity is discussed.
鱼藤酮是一种源自鱼藤根的杀虫剂和鱼毒剂。其细胞毒性机制作用于线粒体水平，影响细胞呼吸。本文描述了一例成人因鱼藤酮中毒自杀的案例。为满足验尸官确定阳性或阴性结果以协助死因调查的主要要求，开发了一种创新的实验室方法。生前检测到的血液浓度为4.05纳克/毫升[0.00405 ppm]，血清浓度为0.55纳克/毫升[0.00055 ppm]。人类中毒情况罕见，因此由于缺乏数据库，毒理学结果的解释变得复杂。根据间接证据以及在1988年《英格兰和威尔士验尸官法》及1984年《验尸官规则》规定的合理可能性平衡基础上的专家病理意见，判定死亡原因是鱼藤酮中毒。本文还讨论了鱼藤酮毒性的法医临床病理学。
