一种模拟磷酸酪氨酸的自固定和荧光非天然氨基酸。
A self-immobilizing and fluorogenic unnatural amino acid that mimics phosphotyrosine.
机构信息
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
出版信息
Chem Commun (Camb). 2011 Oct 21;47(39):10939-41. doi: 10.1039/c1cc14653j. Epub 2011 Sep 12.
PMID:21909540
Abstract
Synthesis of the first self-immobilizing, fluorogenic unnatural amino acid that mimics phosphotyrosine (pTyr) is reported. By using solid-phase peptide synthesis, it was subsequently incorporated into peptide-based probes which found applications in bioimaging and fluorescence-activated cell sorting (FACS).
摘要
本文报道了首例模拟磷酸酪氨酸 (pTyr) 的自固缩、荧光非天然氨基酸的合成。通过固相肽合成，随后将其掺入基于肽的探针中，该探针在生物成像和荧光激活细胞分选 (FACS) 中有应用。
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