Department of Pharmaceutical Science, Faculty of Health, Medical Sciences, Indigenous & Alternative Systems of Medicine, Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad 211007, India.
Nanoscale. 2011 Oct 5;3(10):4104-8. doi: 10.1039/c1nr10661a. Epub 2011 Sep 12.
A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg(-1) was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.
一种新型甲醇衍生石墨烯（MDG）和硫酸庆大霉素纳米杂化物被制备，并研究了庆大霉素在 MDG 上的负载和释放行为。在 pH 7 时，获得了 2.57mgmg(-1)的高效药物负载量。通过应用释放动力学模型，发现药物从 MDG 基质中的释放机制遵循 Korsmeyer-Peppas 模型。然而，扩散释放指数（n）值低于 0.5，表明控制药物释放的机制是菲克扩散。
