Butler T, Cartagenova M, Dunn D
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock 79430.
J Antimicrob Chemother. 1990 Apr;25(4):629-34. doi: 10.1093/jac/25.4.629.
To evaluate the difluorinated quinolone lomefloxacin in murine typhoid, mice were inoculated intraperitoneally with the LT-2 strain of Salmonella typhimurium and treated with graded doses of the drug given once daily by an orogastric needle. Treatment with lomefloxacin for seven days reduced mortality with a 50% effective dose of 2.5-7.8 mg/kg/day. When given once daily for three days, doses greater than or equal to 5 mg lomefloxacin/kg/day caused significant reductions in splenic counts of S. typhimurium and prevented the inflammatory response to infection in the spleen.
为评估二氟喹诺酮洛美沙星对鼠伤寒的疗效，给小鼠腹腔注射鼠伤寒沙门氏菌LT-2菌株，并用灌胃针每日一次给予不同剂量的该药物进行治疗。用洛美沙星治疗七天可降低死亡率，半数有效剂量为2.5 - 7.8毫克/千克/天。当每日一次给药三天时，洛美沙星剂量大于或等于5毫克/千克/天可显著减少脾脏中鼠伤寒沙门氏菌的数量，并预防脾脏对感染的炎症反应。
