Bonina L, Carbone M, Mastroeni P, Costa G B, Mastroeni P
Microbiology Institute, Medical School, Messina University, Italy.
J Chemother. 1992 Dec;4(6):353-7. doi: 10.1080/1120009x.1992.11739191.
This study was undertaken to investigate the efficacy of rufloxacin, a new quinolone which is interesting due to its pharmacokinetics characterized by a long plasma half-life, in the treatment of systemic salmonella infections in the mouse typhoid model. Innately susceptible BALB/c and resistant CBA mice were used to investigate the efficacy of rufloxacin in controlling systemic salmonella infections when given for brief or prolonged periods. The present study shows that rufloxacin is not only very effective on both mouse strains, but can completely eradicate the salmonellae from livers and spleens when given early in the infection of CBA resistant mice.
本研究旨在调查鲁氟沙星（一种新型喹诺酮类药物，因其药代动力学特征为血浆半衰期长而备受关注）在小鼠伤寒模型中治疗全身性沙门氏菌感染的疗效。使用先天易感的BALB/c小鼠和抗性CBA小鼠来研究鲁氟沙星在短期或长期给药时控制全身性沙门氏菌感染的疗效。本研究表明，鲁氟沙星不仅对两种小鼠品系都非常有效，而且在CBA抗性小鼠感染早期给药时，能够完全清除肝脏和脾脏中的沙门氏菌。
