Department of Obstetrics and Gynecology, Ergani State Hospital, Mega Center Karsisi, Polis Loj. Sok., Murat 6 Apt., Kat:6 No:25, 21280 Diyarbakir, Turkey.
Arch Gynecol Obstet. 2012 Mar;285(3):767-70. doi: 10.1007/s00404-011-2077-5. Epub 2011 Sep 10.
To investigate the clinical features of patients with polycystic ovary syndrome (PCOS) and compare the patients with hirsutism to those without.
In total, 304 consecutive females with PCOS were evaluated. The cases were divided into two groups of hirsute or non-hirsute. The risk factors recorded were age, age at menarche, body mass index (BMI), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol, prolactin, and total testosterone (tT) levels and hirsutism scores. Statistical analyses were performed using the Student's t test and logistic regression.
Of all the cases, 224 were hirsute (hirsutism score ≥ 8). No significant difference was observed between the groups for age or age at menarche. BMI and hormone levels, including LH, FSH, estradiol and tT, were higher in hirsute patients than those in non-hirsute patients (p < 0.05). The logistic regression model showed that BMI, tT, LH, and estradiol were significant risk factors with odds ratios and 95% confidence intervals of 5.81 (2.22-15.18), 4.57 (2.34-8.90), 2.61 (1.73-3.94), and 2.29 (1.30-4.05), respectively.
Hirsute patients with PCOS have different clinical characteristics from those that are non-hirsute in terms of BMI, LH, FSH, estradiol, and tT levels. We also determined the odds ratios of these different parameters. BMI was the most important risk factor for the degree of hirsutism.
探讨多囊卵巢综合征（PCOS）患者的临床特征，并比较多毛症患者与无多毛症患者的差异。
共评估了 304 例连续的 PCOS 女性患者。将病例分为多毛组和非多毛组。记录的危险因素包括年龄、初潮年龄、体重指数（BMI）、促黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇、催乳素和总睾酮（tT）水平及多毛评分。采用 Student's t 检验和逻辑回归进行统计学分析。
所有病例中，224 例患者有多毛症（多毛评分≥8）。多毛组与非多毛组之间的年龄或初潮年龄无显著差异。多毛症患者的 BMI 及激素水平（包括 LH、FSH、雌二醇和 tT）均高于非多毛症患者（p＜0.05）。逻辑回归模型显示，BMI、tT、LH 和雌二醇是显著的危险因素，其比值比（OR）和 95%置信区间（CI）分别为 5.81（2.22-15.18）、4.57（2.34-8.90）、2.61（1.73-3.94）和 2.29（1.30-4.05）。
与非多毛症患者相比，多毛症 PCOS 患者在 BMI、LH、FSH、雌二醇和 tT 水平方面具有不同的临床特征。我们还确定了这些不同参数的 OR。BMI 是多毛严重程度的最重要危险因素。
