Lumezi Besa Gacaferri, Berisha Violeta Lokaj
Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo.
Postepy Dermatol Alergol. 2021 Dec;38(6):1006-1010. doi: 10.5114/ada.2020.98132. Epub 2020 Sep 15.
Obese woman with hirsutism have increased risk for developing insulin resistance and diabetes mellitus.
To evaluate patients with hirsutism, report the hormone levels, body mass index (BMI), insulin resistance and diabetes in our study population and compare our results with those of similar research conducted in other countries.
Hormones were measured with radioimmunoassay/immunoradiometric assay methods. Oral glucose tolerance test was done only in a selected group of women (with positive anamnesis for diabetes, women with polycystic ovary syndrome (PCOS) and overweight/obese women). The level of blood glucose was measured after drinking the liquid containing 75 g glucose. Blood was taken to measure glucose, insulin and C-peptide levels after 30 min, 60 min and 3 h.
Women with PCOS (27.4%) had higher BMI than women with other causes of hirsutism. Among 135 of the women with hirsutism, 9.6% were underweight, 60% were with normal weight, 20.7% were overweight and 9.6% were obese. Obesity was more frequent in PCOS and hyperandrogenism groups. Women with hirsutism had higher levels of androstenedione, dehydroepiandrosterone sulfate (DHEAS), total testosterone, free testosterone, lower levels of sex hormone-binding globulin (SHBG). Insulin resistance was present in 20 (14.8%) women and diabetes in 2 (1.4%) women.
Obesity was associated with increased hirsutism. In our study we found that insulin resistance should be assessed in hirsute women with PCOS regardless of their BMI as insulin resistance was found in hirsute women irrespective of whether they were overweight, obese, of normal weight or underweight. Groups at risk (hirsute, obese, diabetes) should be identified and treated.
患有多毛症的肥胖女性患胰岛素抵抗和糖尿病的风险增加。
评估多毛症患者，报告我们研究人群中的激素水平、体重指数（BMI）、胰岛素抵抗和糖尿病情况，并将我们的结果与其他国家进行的类似研究结果进行比较。
采用放射免疫分析/免疫放射分析方法测定激素。仅对一组选定的女性进行口服葡萄糖耐量试验（有糖尿病阳性病史的女性、多囊卵巢综合征（PCOS）女性以及超重/肥胖女性）。饮用含75g葡萄糖的液体后测量血糖水平。在30分钟、60分钟和3小时后采集血液以测量葡萄糖、胰岛素和C肽水平。
PCOS女性（27.4%）的BMI高于其他多毛症病因的女性。在135名多毛症女性中，9.6%体重过轻，60%体重正常，20.7%超重，9.6%肥胖。肥胖在PCOS和高雄激素血症组中更为常见。多毛症女性的雄烯二酮、硫酸脱氢表雄酮（DHEAS）、总睾酮、游离睾酮水平较高，性激素结合球蛋白（SHBG）水平较低。20名（14.8%）女性存在胰岛素抵抗，2名（1.4%）女性患有糖尿病。
肥胖与多毛症增加有关。在我们的研究中，我们发现无论BMI如何，患有PCOS的多毛症女性都应评估胰岛素抵抗，因为无论她们是超重、肥胖、体重正常还是体重过轻，多毛症女性中均发现了胰岛素抵抗。应识别并治疗高危人群（多毛症、肥胖、糖尿病）。
