Moini Ashraf, Shirzad Nooshin, Ahmadzadeh Marzieh, Hosseini Reihaneh, Hosseini Ladan, Sadatmahalleh Shahideh Jahanian
Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ; Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Int J Fertil Steril. 2015 Apr-Jun;9(1):1-8. doi: 10.22074/ijfs.2015.4201. Epub 2015 Apr 21.
Given the relationship of vitamin D deficiency with insulin resistance syndrome as the component of polycystic ovary syndrome (PCOS), the main aim of this study was to compare serum level of 25hydroxyvitamin D [25(OH)D] between PCOS patients and normal individuals.
A cross sectional study was conducted to compare 25(OH)D level between117 normal and 125 untreated PCOS cases at our clinic in Arash Hospital, Tehran, Iran, during 2011-2012. The obtained levels of 25(OH)D were classified as follows: lower than 25 nmol/ml as severe deficiency, between 25-49.9 nmol/ml as deficiency, 50-74.9 nmol/ml as insufficiency, and above 75 nmol/ml asnormal. In addition, endocrine and metabolic variables were evaluated.
Among PCOS patients, our findings shows 3(2.4%) normal, 7(5.6%) with insufficiency, 33(26.4%) with deficiency and 82(65.6%) with severe deficiency, whereas in normal participants, 5(4.3%) normal, 4(3.4%) with insufficiency, 28(23.9%) with deficiency and 80(68.4%) with severe deficiency. Comparison of 25(OH)D level between two main groups showed no significant differences (p= 0.65). Also, the calcium and 25(OH)D levels had no significant differences in patients with overweight (p=0.22) and insulin resistance (p=0.64). But we also found a relationship between 25(OH)D level and metabolic syndrome (p=0.01). Furthermore, there was a correlation between 25(OH)D and body mass index (BMI) in control group (p=0.01), while the C-reactive protein (CRP) level was predominantly higher in PCOS group (p<0.001).
Although the difference of 25(OH)D level between PCOS and healthy women is not significant, the high prevalence of 25(OH)D deficiency is a real alarm for public health care system and may influence our results.
鉴于维生素D缺乏与作为多囊卵巢综合征（PCOS）组成部分的胰岛素抵抗综合征之间的关系，本研究的主要目的是比较PCOS患者与正常个体之间的血清25羟维生素D [25(OH)D]水平。
2011 - 2012年期间，在伊朗德黑兰阿拉什医院我们的诊所进行了一项横断面研究，以比较117名正常人和125名未经治疗的PCOS患者的25(OH)D水平。所获得的25(OH)D水平分类如下：低于25 nmol/ml为严重缺乏，25 - 49.9 nmol/ml为缺乏，50 - 74.9 nmol/ml为不足，高于75 nmol/ml为正常。此外，还评估了内分泌和代谢变量。
在PCOS患者中，我们的研究结果显示3例（2.4%）正常，7例（5.6%）不足，33例（26.4%）缺乏，82例（65.6%）严重缺乏；而在正常参与者中，5例（4.3%）正常，4例（3.4%）不足，28例（23.9%）缺乏，80例（68.4%）严重缺乏。两个主要组之间25(OH)D水平的比较无显著差异（p = 0.65）。此外，超重患者（p = 0.22）和胰岛素抵抗患者（p = 0.64）的钙和25(OH)D水平也无显著差异。但我们还发现25(OH)D水平与代谢综合征之间存在关联（p = 0.01）。此外，对照组中25(OH)D与体重指数（BMI）之间存在相关性（p = 0.01），而PCOS组的C反应蛋白（CRP）水平明显更高（p < 0.001）。
尽管PCOS患者与健康女性之间25(OH)D水平的差异不显著，但25(OH)D缺乏的高患病率对公共卫生保健系统来说是一个真正的警示，并且可能影响我们的研究结果。
