Kinashi Tatsuo
Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Osaka, Japan.
Methods Mol Biol. 2012;757:261-78. doi: 10.1007/978-1-61779-166-6_17.
It has been well established that integrins mediate cell-cell and cell-matrix adhesion and play crucial roles in the immune system such as leukocyte-endothelium interactions, immune synapse formation, and effector functions. Since the discovery that integrins undergo dynamic changes of adhesive activities in response to external stimuli, intensive studies have been conducted to elucidate the signaling events that control the activation of integrins (inside-out signaling) and signaling events from the induced integrin-dependent adhesion (outside-in signaling). The molecular characterization of these signaling pathways highlights the importance of integrins as bidirectional signaling receptors. The characteristics of integrin signaling are best exemplified in the immune system. This chapter highlights the recent studies of intracellular signaling pathways that regulate integrins in immunological contexts.
整合素介导细胞间和细胞与基质间的黏附，并在免疫系统中发挥关键作用，如白细胞与内皮细胞相互作用、免疫突触形成及效应功能，这一点已得到充分证实。自从发现整合素会响应外部刺激而发生黏附活性的动态变化以来，人们进行了深入研究，以阐明控制整合素激活的信号事件（由内向外信号传导）以及由诱导的整合素依赖性黏附引发的信号事件（由外向内信号传导）。这些信号通路的分子特征突出了整合素作为双向信号受体的重要性。整合素信号传导的特征在免疫系统中体现得最为明显。本章重点介绍了近期在免疫背景下调节整合素的细胞内信号通路的研究。
