临床蛋白质组学揭示非侵袭性乳腺导管癌的脆弱性并推动个性化治疗策略
Clinical Proteomics Reveals Vulnerabilities in Noninvasive Breast Ductal Carcinoma and Drives Personalized Treatment Strategies.
作者信息
Mitsa Georgia, Florianova Livia, Lafleur Josiane, Aguilar-Mahecha Adriana, Zahedi Rene P, Del Rincon Sonia V, Basik Mark, Borchers Christoph H, Batist Gerald
机构信息
Division of Experimental Medicine, McGill University, Montréal, Canada.
Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital and McGill University, Montréal, Canada.
出版信息
Cancer Res Commun. 2025 Jan 1;5(1):138-149. doi: 10.1158/2767-9764.CRC-24-0287.
This study provides real-world evidence for DCIS, a disease for which currently no molecular tools or biomarkers exist, and gives an unbiased, comprehensive, and deep proteomic profile, identifying >380 actionable targets.
本研究为导管原位癌（DCIS）提供了真实世界的证据，目前针对该疾病尚无分子工具或生物标志物，并且给出了一个公正、全面且深入的蛋白质组学概况，确定了超过380个可采取行动的靶点。
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